ea0049ep790 | Endocrine tumours and neoplasia | ECE2017
Jimenez-Vacas Juan M
, Gahete Manuel D
, Pedraza-Arevalo Sergio
, del Rio-Moreno Mercedes
, Hormaechea-Agulla Daniel
, Gomez-Gomez Enrique
, Carrasco-Valiente Julia
, del Mar Moreno Maria
, Jose Requena-Tapia Maria
, Castano Justo P
, Luque Raul M
: Prostate cancer (PCa) is the most common cancer among men in developed countries. Unfortunately, the heterogeneity of this malignancy hinders the finding of new biomarkers and therapeutic tools. A potential factor contributing to PCa is alternative splicing, which can generate the appearance of oncogenic variants involved in PCa aggressiveness. Thus, we hypothesized that the alteration of the splicing machinery (spliceosome components and splicing factors (SFs)) could be ass...